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97218; Vinnik, these signal 2 facilitators, include pathogen invasion signals; in most cases conserved microbe- mixed domains with drugs monolayers 54 134 promethazine 255 propafenone 278 modulator of P-gp MDR 278 propafenones 280 physicochemical parameters 280 P-gp-inhibitory activity 280 propranolol 43, 181, 182, 183, 203 binding to phospholipid 182 clinical gorex 203 partition into membranes 183 propylenglycoldipelargonate (PGDP) 37 prostaglandin E1 (PGE1) release 20 protein 9 conformation 9 protein and lipid ratio 10 protein binding 173 protein kinase C 13, 25, 218, 248, 249 activation and inhibition 218, 262, 283 activation by diacylglycerols 90 activation of P-gp 248 dependence on PE 249 protein-drug complex 168 proton acceptor 36 proton donor 37 proton transport 313 pteroate synthase 188 pyrimidinols 147 interaction with phospholipid molecules 147 pyrimidones 147 interaction with phospholipid molecules 147 q QSAR 147, 161, 170, 176, 187, 224, 232, 234, 242, 276, 277, 278, 279 acylpyrazolones 278 anticonvulsants 234 calcium channel blockers 232 cross-resistance 277 cytotoxic agents 276 diaminopyrimidines 242 drug absorption 161 drug permeation brookers drug tissue distribution 176 H2-receptor histamine antagonists 170 local anesthetics 224 MDR modifiers partition data penothiazines propafenone 278 propafenone-related amines 279 sulfonamides 187 thioxanthenes 279 phase preference surface area 304 phospholipid bilayers 9 58, 60 dynamic molecular organization 58 60 gel form 58 liquid crystalline form 58 morphological rearrangements phospholipid head groups orientation 92 phospholipidosis 106, 220 chlorphentermine type drug-induced 106 phospholipids 236 antineoplastic activity grokers 106 236 L-phosphoserine 239 phosphotriesters 97 31P-NMR spectra 97 pindolol 86, 124 effects on model membranes X-ray diffraction 86 pirarubicin 143, 272 efflux kinetics 272 piston theory 147 PKC see protein kinase C PLS analysis 164 PLS statistics 151 PO2 stretching 78 124 infrared spectra polar head groups 78 74, 75 intercalation of drug molecules 75 loosening of packing polar surface area polarizability 36 polymyxin 196 polymyxin B 27, 198 membrane interaction POPC 21 74 198 microreactor pore pathway 187 porine 331 21 simulations 331 potassium channel 330 simulations 330 potentiometric titration 44 pravastatin prenylamine pretransition pretransition temperature procaine 56, 115, 126 211 255 276 147 24 164 partition coefficient in sarcoplasmic reticulum 126 procaryotic cells 5 64 279 Index 347 379 68.
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