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The putative 4-adrenergic receptor had been postulated on the basis of functional assays on isolated organs and ligand binding assays, in which high concentrations of the -receptor antagonist CGP12177 produced cardiostimulatory effects .
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Then the (unbounded) linear operator A on H is defined by We shall show also that this A is self-adjoint, of which notion is described in the following paragraph.
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